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Bisphosphonate Induced Osteonecrosis of the Jaw
By: David D. Rolf II, D.M.D., M.Sc.
Director of Education Dental1.org
Complications
Side Effects Associated with Bisphosphonate Osteoporosis Drugs
As with most drugs, side effects can occur and can range from mild to more severe types of problems. One potentially harmful side effect of taking bisphosphonate tablets by mouth is irritation or erosion of the esophagus (the “food tube” connecting the mouth and the stomach). This is why patients are advised to take these medicines with a full glass of water, on an empty stomach and to not eat, lay down or go to sleep for at least 30 minutes afterward.
Complications associated with Bisphosphonate-Induced Osteonecrosis of the Jaw
Patients suffering from Bisphosphonate-Induced Osteonecrosis of the Jaw (BON) may experience the following complications:
Infection, which can lead to cellulitis, a more serious bacterial infection that can spread and can be life-threatening. This complication may require a short hospitalization and treatment with IV antibiotics such as ampicillin and clavulonate.
Some patients with BON may have delayed healing or problems with non-healing of oral wounds associated with the exposed necrotic bone.
Patients are not advised to have invasive surgical procedures to treat BON, as these procedures have led to further exposed bone, worsening of symptoms, and a greater risk for jaw fracture.
Some complications of BON may take years to develop and to be recognized clinically.
Last updated: 22-Dec-06
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